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571 2014 HTN : Osteogenic Factors Regulate Vascular Function Through Reactive Oxygen Species And Toll-Like Receptor 4 Activation: Role In Hypertension.

Researchers

Presenter

  • Rheure A Lopes

Principal Investigators

  • Dylan E Burger

  • Delyth Graham

  • Rhian M Touyz

  • Augusto C Montezano

Medical Centers

  • BHF-GCRC, Institute of Cardiovascular and Medical Sciences, Glasgow, United Kingdom

  • Kidney Res Ctr - Univ of Ottawa, Ottawa, ON, Canada

Locations

  • Canada

  • United Kingdom

Companies

  • N/A

Study Components

Therapeutic Area

  • Cardiovascular (CVS)

Disease

  • Vasodilation dysfunction

  • Calcified vascular disease

  • Hypertension

Biomarkers

  • Mitogen-activated protein kinase

  • Mitogen-activated protein kinase 3

  • Nucleoside diphosphate kinase A

  • Osteoprotegerin

  • c-Jun N-terminal kinase

  • Proto-oncogene tyrosine-protein kinase ROS

  • Superoxide dismutase

Drug/Treatment

  • N-acetylcysteine

  • Acetylcholine

  • Phenylephrine

  • Setanaxib

  • Tempol

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Interim

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