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343 2014 HTN : Endothelin-1 Overexpression Preserves Endothelial Function In Mice With Vascular Smooth Muscle Cell-specific Deletion Of Ppar-gamma

Researchers

Presenter

  • Sofiane Ouerd

Principal Investigators

  • Tlili Barhoumi

  • Ernesto L Schiffrin

  • Michelle Trindade

  • Jordan Gornitsky

  • Asia Rehman

  • Stefan Offermanns

  • Frank J Gonzalez

  • Pierre Paradis

Medical Centers

  • Natl Cancer Inst, Natl Insts of Health, Bethesda, MD

  • Dept of Pharmacology, Max-Planck-Inst for Heart and Lung Res, Bad Nauheim, Germany

  • Lady Davis Inst. for Med. Rsch., Montreal, QC, Canada

Locations

  • United States

  • Germany

  • Canada

Companies

  • N/A

Study Components

Therapeutic Area

  • Angiology

Disease

  • Vasodilation dysfunction

  • Calcified vascular disease

Biomarkers

  • Peroxisome proliferator activated receptor

  • Proto-oncogene tyrosine-protein kinase ROS

  • Endothelin-1

  • Fibronectin

Drug/Treatment

  • Nitroprusside sodium

  • Angiotensin II

  • Acetylcholine

  • endothelin-1

  • Nitric oxide

  • DE-074

  • Tamoxifen

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Interim

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