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458 2015 ATVB : Loss of Smooth Muscle ?-actin in Mice Results in Thoracic Aortic Aneurysms via Increased Reactive Oxygen Species, Increased Nox4,and Increased Angiotensin II type 1 Receptor-Mediated Signaling

Researchers

Presenter

  • Callie Kwartler

Principal Investigators

  • Christina L. Papke

  • Yong-Jian Geng

  • Allan R. Brasier

  • Elaine C. Davis

  • Siddharth Prakash

  • Dianna M. Milewicz

  • Andrew Peters

  • Lea-Jeanne Ringuette

  • Jiumei Cao

  • Shanzhi Wang

  • Carlos Villamizar

  • Katerina L. Byanova

  • Rosalinda Madonna

  • Patrick Kee

Medical Centers

  • University of Montreal, Montreal, QC, Canada

  • The University of Texas Health Science Center at Houston, Houston, TX

  • The University of Texas Medical Branch, Galveston, TX

Locations

  • United States

  • Canada

Companies

  • N/A

Study Components

Therapeutic Area

  • N/A

Disease

  • N/A

Biomarkers

  • Nicotinamide adenine dinucleotide phosphate oxidase

  • Proto-oncogene tyrosine-protein kinase ROS

  • Interleukin 6

  • Matrix metalloproteinase 2

  • Solute Carrier Family 33 Member 1

  • Nicotinamide-adenine dinucleotide phosphate oxidase 4

Drug/Treatment

  • Angiotensin II

  • ILS-969

  • Interleukin

  • Cysteine Hydrochloride

  • Lorestan

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Interim

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