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S4089 2016 AHA : Reduced Loop Diuretic Use in Patients Taking Sacubitril/Valsartan Compared With Enalapril: The Paradigm-HF Study

Researchers

Presenter

  • Brian Claggett

Principal Investigators

  • Jessica Kachadourian

  • Milton Packer

  • Michael Zile

  • Jean Rouleau

  • Karl Swedberg

  • Victor Shi

  • Martin Lefkowitz

  • John McMurray

  • Scott D Solomon

Medical Centers

  • Brigham & Women's Hospital, Boston, MA

  • University of Montreal, Montreal, QC, Canada

  • Medcl Univ of South Carolina, Charleston, SC

  • University of Glasgow, Glasgow, United Kingdom

  • Baylor Univ. Medical Ctr., Dallas, TX

  • Univeristy of Wisconsin, Madison, WI

  • Univeristy of Gothenburg, Gothenburg, Sweden.

Locations

  • United States

  • Canada

  • United Kingdom

  • Sweden

Companies

  • Novartis AG

Study Components

Therapeutic Area

  • Cardiovascular (CVS)

Disease

  • Heart failure with reduced ejection fraction

Biomarkers

  • N/A

Drug/Treatment

  • Sacubitril/valsartan

  • Bumetanide

  • furosemide GR

  • Sacubitril

  • Enalapril maleate

  • Torsemide

  • Valsartan

Outcome

  • N/A

Study Design

  • randomized

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Interim

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