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M1168 2016 AHA : PI3K? Deletion in Cardiomyocytes Causes Maintained Mitochondrial Membrane Potential and Blocks Necrotic Cell Death in Ischemia/Reperfusion Injury

Researchers

Presenter

  • Pavel Zhabyeyev

Principal Investigators

  • Xueyi Chen

  • Alois Haromy

  • Bart Vanhaesebroeck

  • Evangelos D Michelakis

  • Gavin Y Oudit

Medical Centers

  • Kings College London, London, United Kingdom

  • Univ. of Alberta, Edmonton, Alberta, Canada.

Locations

  • Canada

  • United Kingdom

Companies

  • N/A

Study Components

Therapeutic Area

  • Cardiovascular (CVS)

Disease

  • Ischemia-reperfusion injury

Biomarkers

  • Mitogen-activated protein kinase 3

  • Dual specificity mitogen-activated protein kinase kinase 1

  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

  • RalA Binding Protein 1

  • Stromal interaction molecule 1

Drug/Treatment

  • Tamoxifen

  • Binimetinib

  • MK 2206

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Interim

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