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M1167 2016 AHA : Doxorubicin Provokes Maladaptive Autophagy and Necrotic Cell Death of Cardiac Myocytes by Disrupting Mitochondrial Respiration Chain Complex IV

Researchers

Presenter

  • Hongying Gang

Principal Investigators

  • Victoria Margulets

  • Lorrie A. Kirshenbaum

Medical Centers

  • St. Boniface Res Ctr, Winnipeg, MB, Canada

Locations

  • Canada

Companies

  • N/A

Study Components

Therapeutic Area

  • Cardiovascular (CVS)

Disease

  • Congestive heart failure

  • Cardiotoxicity

Biomarkers

  • Nucleoside diphosphate kinase A

  • Proto-oncogene tyrosine-protein kinase ROS

  • Cyclooxygenase-1

  • Lactate dehydrogenase

Drug/Treatment

  • Doxorubicin

Outcome

  • N/A

Study Design

  • adaptive

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Interim

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