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P226 2016 HTN : Endothelin-1 Overexpression Exaggerates Diabetes-induced Endothelial Dysfunction by Altering Oxidative Stress

Researchers

Presenter

  • Noureddine Idris-Khodja

Principal Investigators

  • Muhammad O. Mian

  • Jordan Gornitsky

  • Tlili Barhoumi

  • Pierre Paradis

  • Ernesto L. Schiffrin

Medical Centers

  • McGill Univ, Sir Mortimer B. Davis-Jewish General Hosp, Lady Davis Inst for Medical Res and Dept of Med, Vascular and Hypertension Res Unit, Montreal, QC, Canada

  • McGill Univ, Sir Mortimer B. Davis-Jewish General Hosp, Lady Davis Inst for Medical Res and Dept of Med, Vascular and Hypertension Res Unit, Montreal, QC, Canada

Locations

  • Canada

Companies

  • N/A

Study Components

Therapeutic Area

  • Endocrine/metabolic Diseases (ME)

Disease

  • Vasodilation dysfunction

  • Diabetes

Biomarkers

  • Proto-oncogene tyrosine-protein kinase ROS

  • Endothelial cell nitric oxide synthase

  • Endothelin-1

Drug/Treatment

  • Superoxide dismutase

  • Streptozotocin

  • Acetylcholine

  • endothelin-1

  • Nitric oxide

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Interim

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