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265 : Desialylation: A Novel Platelet Clearance Mechanism and a Potential New Therapeutic Target in Anti-GPIb Antibody Mediated Thrombocytopenia

Researchers

Presenter

  • Guangheng Zhu

Principal Investigators

  • June Li

  • Brian Vadasz

  • Yougbare Issaka

  • Sean Lang

  • John Freedman

  • Heyu Ni

Medical Centers

  • Departments of Laboratory Medicine and Pathobiology, Medicine, St. Michael's Hospital and University of Toronto, Toronto, ON, Canada

  • Toronto Platelet Immunobiology Group, University of Toronto, Toronto, ON, Canada

  • Toronto Platelet Immunobiology Group, Department of Laboratory Medicine, The Keenan Research Centre in the Li Ka Shing Knowledge Institute of St. Michael's Hospital, Toronto, ON, Canada

  • Transfusion medicine, LKSKI-Keenan Research Center, St. Michael's Hospital, Toronto, Canada

  • Station of St. Michael's Hospital Transfusion Medicine, Canadian Blood Services/University of Toronto, Toronto, ON, Canada

  • Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada

  • Australian Centre For Blood Diseases, Monash University, Melbourne, Australia

Locations

  • Canada

  • Australia

Companies

  • N/A

Study Components

Therapeutic Area

  • Autoimmune (AI)

Disease

  • Immune thrombocytopenia

Biomarkers

  • Cluster of Differentiation 11b Antigen

  • Immunoglobulin G

Drug/Treatment

  • Phosphatidylserine

  • Glucosamine

  • Neuraminidase

  • IVIG

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Interim

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