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545 : High Incidence of EZH2 Mutations with Variable Mutation Load in Follicular Lymphoma and Its Consequences for EZH2 Targeted Therapy

Researchers

Presenter

  • Grossmann Vera

Principal Investigators

  • Silvia Montoto

  • Janet Matthews

  • Sameena Iqbal

  • Hajnalka Rajnai

  • Andreas Rosenwald

  • German Ott

  • Elias Campo

  • Erlend B. Smeland

  • Wing C. Chan

  • Rita M. Braziel

  • King Tan

  • Louis M. Staudt

  • George Wright

  • Lisa M. Rimsza

  • T. Andrew Lister

  • Olivier Elemento

  • John G Gribben

  • Andras Matolcsy

  • Torsten Haferlach

  • Randy D. Gascoyne

  • Jessica Okosun

  • Jude Fitzgibbon

  • Nikolay Popov

  • Shamzah Araf

  • Jacek Marzec

  • Ciaran ORiain

  • Abigail Lee

  • Andrew James Clear

Medical Centers

  • Department of Clinical Pathology, Oregon Health & Department of Pathology, University of Wuerzburg, Wuerzburg, Germany

  • Centre for Lymphoid Cancer, British Columbia Cancer Agency, Vancouver, British Columbia, Canada

  • Hematology/Oncology, University of Nebraska Medical Center, Omaha, NE

  • Department of Medical Oncology, BC Cancer Agency Center for Lymphoid Cancer, Vancouver, BC, Canada

  • Institute of Cancer, Centre for Medical Oncology, Barts and The London School of Medicine, University of London, London, United Kingdom

  • Munich Leukemia Laboratory, Munich, Germany.

  • Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom

  • Portland, OR, USA,

  • 1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary

  • Department of Immunology and Centre for Cancer Biomedicine, Oslo University Hospital, Oslo, Norway

  • Hematologia, Hospital Clinic, Barcelona, Spain

Locations

  • Canada

  • Norway

  • Germany

  • Spain

  • United Kingdom

  • United States

  • Hungary

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Follicular lymphoma

  • Solid malignancies

Biomarkers

  • Polycomb repressive complex 2

  • Histone-lysine N-methyltransferase 2A

  • Trimethylation of lysine 27 on histone H3

Drug/Treatment

  • EZH2

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Interim

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