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1586 : A 7-Gene Microrna Signature Characteristic of Mantle Cell Lymphoma Reveals Focal Adhesion and Integrin Signalling, Proteasome-Mediated Degradation, and the PI3K Signalling Cascade As Important to MCL Pathogenesis

Researchers

Presenter

  • Yali Xuan

Principal Investigators

  • Wilson Lam

  • Alanna Church

  • David LeBrun

  • Laurie H. Sehn

  • Pedro Farinha

  • Igor Jurisica

  • Denis Bailey

  • Randy D. Gascoyne

  • Michael Crump

  • Suzanne Kamel-Reid

  • Mahadeo A. Sukhai

  • Patricia P Reis

  • Thomas Sun

  • Alessandro Datti

  • Wei Xu

  • John Kuruvilla

  • David Good

  • Raymond Lai

Medical Centers

  • Department of Surgery and Orthopedics, Sao Paulo State University - UNESP, Botucatu, Brazil

  • Division of Signalling Biology, Ontario Cancer Institute and the Campbell Family Institute for Cancer Research, Toronto, ON, Canada

  • Toronto, ON, Canada

  • Division of Medical Oncology and Hematology, Princess Margaret Hospital, University Health Network, Toronto, ON, Canada,

  • Cancer Biology and Genetics, Queen's University, Kingston, ON, Canada

  • Department of Pathology and Molecular Medicine, Queen's University/Kingston General Hospital, Kingston, ON, Canada

  • Department of Pathology and Molecular Medicine, Queen's University/Kingston General Hospital, Kingston, ON, Canada

  • Department of Medical Oncology, BC Cancer Agency Center for Lymphoid Cancer, Vancouver, BC, Canada

  • Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada

  • Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, Toronto, ON, Canada

  • Department of Medical Oncology, British Columbia Cancer Agency, Vancouver, BC, Canada

  • Department of Biostatistics, Princess Margaret Cancer Centre, Toronto, ON, Canada

  • Toronto General Hospital, University of Toronto, Toronto, ON, Canada

  • Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.

  • Hematology/Oncology, Princess MArgaret Hospital, Toronto, ON, Canada

  • Applied Molecular Oncology, Princess Margaret Hospital, Toronto, ON, Canada

  • Centre for Lymphoid Cancer, British Columbia Cancer Agency, Vancouver, British Columbia, Canada

Locations

  • Brazil

  • Canada

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • B-Cell Non-Hodgkin Lymphoma

  • Mantle cell lymphoma

  • Non-Hodgkin's Lymphoma

  • Non‐Hodgkin Lymphoma

  • B cell lymphomas

  • Hodgkin's Lymphoma

  • Lymphomas

Biomarkers

  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

  • PI3K/AKT

Drug/Treatment

  • N/A

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Interim

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