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4195 : The Anti-CD25 Antibody Daclizumab Delays Treg Reconstitution, Promotes CD4 Memory, and Does Not Prevent Acute or Chronic Gvhd After Allogeneic Stem Cell Transplantation

Researchers

Presenter

  • Joseph Pidala

Principal Investigators

  • Barry Storer

  • Ginna G Laport

  • Auayporn Nademanee

  • Raymond Powles

  • Armand Keating

  • Gerard Socie

  • Claudio Anasetti

  • Jianing Fu

  • Maritza Lienlaf

  • Paul J. Martin

  • Michael A Pulsipher

  • Thomas Chauncey

  • Niels Jacobsen

  • Nikolaus Kroeger

  • Irwin Walker

  • Mary C Territo

  • Susan Light

Medical Centers

  • University of Utah Medical Center, Salt Lake City, UT

  • Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada

  • Hematology/Transplantation, Hospital Saint Louis, Paris, France

  • Center of Oncology - Bone Marrow Transplantation Unit, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

  • Princess Margaret Hospital, Toronto, ON, Canada

  • Division of Blood and Marrow Transplantation, Stanford University School of Medicine, Stanford, CA

  • Oncology-Prot R Powles, Parkside Oncology Clinic, Wimbledon, United Kingdom

Locations

  • Canada

  • Germany

  • United Kingdom

  • United States

  • France

Companies

  • Bristol-Myers Squibb

Study Components

Therapeutic Area

  • Autoimmune (AI)

Disease

  • Graft-versus-host disease

  • Hematological malignancies

  • Aplastic anemia

  • Anemia

Biomarkers

  • Breakpoint Cluster Region

  • C-C Motif Chemokine Receptor 7

  • Cluster of Differentiation 4

  • Protein Tyrosine Phosphatase, Receptor Type C

  • Forkhead Box P3

  • Interleukin-2

  • Major Histocompatibility Complex, Class I, A

  • Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Epsilon

  • Regulatory T cells

Drug/Treatment

  • Cyclosporine eent

  • Methotrexate

  • Daclizumab

  • C-83

Outcome

  • N/A

Study Design

  • randomized

  • double blind/blinded

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Interim

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