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1023 : Sildenafil Therapy in Patients with Thalassemia and an Elevated Tricuspid Regurgitant Jet Velocity (TRV) On Doppler Echocardiography At Risk for Pulmonary Hypertension: Report From the Thalassemia Clinical Research Network

Researchers

Presenter

  • Hae-Young Kim

Principal Investigators

  • John C Wood

  • Ali T Taher

  • Ellis J. Neufeld

  • Alexis A. Thompson

  • Vandana Sachdev

  • Sandra K Larkin

  • Jung H Suh

  • Frans A Kuypers

  • Elliott Vichinsky

  • Felicia Trachtenberg

  • Elizabeth S Klings

  • John B. Porter

  • Nancy Sweeters

  • Patrick BWalter

  • Nancy F Olivieri

  • Janet L. Kwiatkowski

  • Sylvia Titi Singer

Medical Centers

  • American University of Beirut (AUB), Beirut, Lebanon

  • Hemoglobinopathy Research, University Health Network, University of Toronto, Toronto, ON, Canada,

  • New England Research Institutes, Watertown, MA

  • Gastroenterology, St Georges Hospital University of London, London, United Kingdom

Locations

  • United States

  • Canada

  • United Kingdom

  • Lebanon

Companies

  • N/A

Study Components

Therapeutic Area

  • Pulmonary/Respiratory Diseases

Disease

  • Pulmonary arterial hypertension

  • Thalassemia

  • Dyspnea

Biomarkers

  • Alanine transaminase

  • Aspartate aminotransferase

Drug/Treatment

  • Nitric oxide

  • Sildenafil citrate

  • Arginine hydrochloride

Outcome

  • N/A

Study Design

  • open label

Phase

  • I/II

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Interim

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