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1662 : Identification of a Unique Autophagy Gene Expression Signature in CD34+ CML Stem/Progenitor Cells That Correlates with Clinical Response to Imatinib Mesylate

Researchers

Presenter

  • Kevin B.L. Lin

Principal Investigators

  • Hanyang Lin

  • Amy Leung

  • Donna L. Forrest

  • Sharon Gorski

  • Xiaoyan Jiang

Medical Centers

  • Genome Sciences Centre, Vancouver, BC, Canada

  • Internal Medicine, Leukemia/Bone Marrow Transplant Program, Division of Hematology, Vancouver, BC, Canada

  • Terry Fox Laboratory, BC Cancer Agency, Vancouver, BC, Canada

  • Genome Sciences Centre, Vancouver, BC, Canada

  • Terry Fox Laboratory, BC Cancer Agency, Vancouver, BC, Canada

Locations

  • Canada

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Chronic Myelogenous Leukemia

Biomarkers

  • Abelson murine leukemia viral oncogene homolog

  • Autophagy Related 4B Cysteine Peptidase

  • Autophagy-related gene 5

  • Breakpoint Cluster Region

  • Cluster of Differentiation 34

  • Cluster of Differentiation 38

  • Protein Tyrosine Phosphatase, Non-Receptor Type 11

Drug/Treatment

  • Imatinib

  • Nilotinib

  • dasatinib

  • Cysteine Hydrochloride

  • IkT001

  • L-Tyrosine

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Interim

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