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Su1277 : Increased Expression of T Cell Associated Genes in Baseline Biopsies From TNF Antagonist NaiVE Patients That Achieve Remission With Etrolizumab Treatment in a Phase II Trial in Moderate to Severely Active Ulcerative Colitis

Researchers

Presenter

  • Jason Hackney

Principal Investigators

  • Stefan Schreiber

  • Iris Dotan

  • William Sandborn

  • John A. Kirby

  • Gert De Hertogh

  • Gert A. Van Assche

  • Paul J. Rutgeerts

  • Sharon -Byrne

  • Adrian C. Hayday

  • Mary E. Keir

  • Christopher A. Lamb

  • Diana Luca

  • Jackson G. Egen

  • Severine Vermeire

  • John C. Mansfield

  • Brian G. Feagan

  • Julian Panes

  • Daniel C. Baumgart

Medical Centers

  • University of California, San Diego, La Jolla, CA

  • Royal Victoria Infirmary University of Newcastle, Newcastle upon Tyne, United Kingdom

  • Kings College London, London, United Kingdom

  • University of Toronto, Toronto, ON, Canada

  • Hospital Clinic Barcelona, Barcelona, Spain

  • University of Western Ontario, London, ON, Canada

  • Sackler Faculty Of Medicine, Tel-Aviv University, Tel-Aviv, Israel

  • University of Leuven, KUL, Leuven, Belgium

  • Charite Medical School - Humboldt-University of Berlin, Berlin, Germany

  • Institute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany

Locations

  • Canada

  • Spain

  • Germany

  • United Kingdom

  • United States

  • Israel

  • Belgium

Companies

  • Genentech, Inc.

Study Components

Therapeutic Area

  • Autoimmune (AI)

Disease

  • Ulcerative colitis

Biomarkers

  • Cadherin 1

  • Cluster of Differentiation 4

  • Cluster of differentiation 8A

  • Tumor necrosis factor

Drug/Treatment

  • Etrolizumab

Outcome

  • N/A

Study Design

  • randomized

  • double blind/blinded

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Interim

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