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Sa1782 : Peripheral Blood CD4 T-Lymphocytes From Crohn's Disease Patients Demonstrate Hyper-Responses to PRO-Inflammatory Cytokines In Vitro by Generating IL-17/FOXP3 Double Expressing Sub-Population

Researchers

Presenter

  • Humberto Jijon

Principal Investigators

  • Kim Ford

  • Ronald Chan

  • Paul L. Beck

  • David L. Sigalet

  • Herman Barkema

  • Gilaad G. Kaplan

  • Remo Panaccione

  • Subrata Ghosh

Medical Centers

  • The Alberta IBD Consortium, University of Calgary, Calgary, AB, Canada

  • Department of Surgery, University of Calgary, Calgary, AB, Canada

Locations

  • Canada

Companies

  • N/A

Study Components

Therapeutic Area

  • Autoimmune (AI)

Disease

  • Inflammatory bowel disease

  • Ulcerative colitis

  • Crohn's disease

Biomarkers

  • Peripheral blood mononuclear cell

  • Cluster of Differentiation 2AP

  • Cluster of Differentiation 4

  • Protein Tyrosine Phosphatase, Receptor Type C

  • Cytokine

  • Forkhead Box P3

  • Interleukin 1 beta

  • Interleukin 17A

  • Interleukin 6

  • Interleukin-21

  • Interleukin-23

  • Regulatory T cells

Drug/Treatment

  • lonomycin

  • Recombinant Interleukin 21

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Interim

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