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Mo1975 : Ileal RNA-Seq Analyses Reveal Decreased Mucosal Myeloid Cell Immune Responses in Pediatric Crohn Disease Patients With Phagocyte Dysfunction Due to Neutralizing Granulocyte Macrophage Colony Stimulating Factor (GM-CSF) Auto-Antibodies

Researchers

Presenter

  • Ingrid Jurickova

Principal Investigators

  • Scott B. Snapper

  • Richard Kellermayer

  • Michael Kappelman

  • Joel R. Rosh

  • Anthony R. Otley

  • Marian D. Pfefferkorn

  • Stanley A. Cohen

  • Ashish S. Patel

  • Barbara S. Kirschner

  • Robert Baldassano

  • Rebekah Karns

  • Marla Dubinsky

  • Thomas D. Walters

  • Bruce J. Aronow

  • Lee Denson

  • Dora Tang

  • Erin L. Bonkowski

  • Benjamin Fey

  • Joshua D. Noe

  • James Markowitz

  • Melvin B. Heyman

  • Wallace Crandall

Medical Centers

  • Nationwide Childrens Center - Ohio, Columbus, OH

  • Childrens Hospital of Philadelphia, Childrens Hospital of Philadelphia, PA

  • Children's Hospital Boston, Boston, MA

  • University of California, San Francisco, San Francisco, CA

  • Sickkids, Toronto, ON, Canada

  • Cincinnati Children's Hospital Medical Center, Cincinnati, OH

  • The Medical College of Wisconsin, Milwaukee, WI

  • IWK Health Centre, Halifax, NS, Canada

  • University of North Carolina, Chapel Hill, NC

  • Baylor College of Medicine, Houston, TX

  • Feinstein Institute for Medical Research, Manhasset, NY

  • Children's Center for Digestive Health Care, Atlanta, GA

  • Cedars-Sinai Medical Center, Los Angeles, CA

  • UTSouthwestern Medical Center, Dallas, TX

  • The University of Chicago Medical Center, Chicago, IL

  • Division of Biomedical Informatics, Cincinnati Childrens Hospital Research Medical Center, Cincinnati, OH

  • Indiana University School of Medicine, Indianapolis, IN

Locations

  • United States

  • Canada

Companies

  • Atlantic Health Syst

Study Components

Therapeutic Area

  • Endocrine/metabolic Diseases (ME)

Disease

  • Dysbiosis

Biomarkers

  • Adenomatous Polyposis Coli

  • Carcinoembryonic antigen related cell adhesion molecule 5

  • C-C Motif Chemokine Ligand 3

  • C-C Motif Chemokine Receptor 7

  • Chemokine (C-X-C motif) ligand 1

  • Cluster of Differentiation 11b Antigen

  • Granulocyte-macrophage-colony stimulating factor

  • Human α-defensin 5

  • Immunoglobulin G

  • Interleukin 1

  • Interleukin 6

  • Signal transducer and activator of transcription 5

  • Tumor necrosis factor

  • Type 1 T helper

Drug/Treatment

  • L-Tyrosine

  • GM-CSF

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Interim

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