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Tu1749 : HIGHER MUCOSAL CALPROTECTIN EXPRESSION IS ASSOCIATED WITH INDUCTION OF ANTIMICROBIAL AND TUMOR NECROSIS FACTOR ALPHA SIGNALING AND REDUCED EFFECTIVENESS OF CORTICOSTEROID THERAPY IN TREATMENT NAIVE PEDIATRIC ULCERATIVE COLITIS

Researchers

Presenter

  • Phillip J. Dexheimer

Principal Investigators

  • Joel R. Rosh

  • Brendan M. Boyle

  • David R. Mack

  • Robert N. Baldassano

  • David J. Keljo

  • Neal S. Leleiko

  • Melvin B. Heyman

  • Anne M. Griffiths

  • Ashish S. Patel

  • Joshua D. Noe

  • Courtney McCall

  • Bruce J. Aronow

  • Subra Kugathasan

  • Thomas D. Walters

  • Sonia Davis

  • Jeffrey S. Hyams

  • Lee A. Denson

  • Alison Marquis

  • Nathan Gotman

  • Paul A. Rufo

  • Susan S. Baker

  • Cary G. Sauer

  • James Markowitz

  • Marian D. Pfefferkorn

Medical Centers

  • Connecticut Childrens Medical Center, Hartford, Connecticut, United States

  • University of California, San Francisco, San Francisco, California, United States

  • Childrens Hospital of Buffalo, Buffalo, New York, United States

  • Toronto Sickkids Hospital for Sick Children, Toronto, Ontario, Canada

  • Childrens Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania , United States

  • Emory Childrens Center, Atlanta, Georgia, United States

  • Goryeb Childrens Hospital/Atlantic Health, Morristown, New Jersey, United States

  • Hasbro Childrens Hospital, Providence, Rhode Island, United States

  • Riley Children's Hospital Indiana University School of Medicine, Indianapollis, Indiana, United States

  • Medical College of Wisconsin, Milwaukee, Wisconsin , United States

  • Cincinnati Childrens Hospital, Cincinnati, Ohio, United States

  • Nationwide Childrens Hospital/Dept. of Anes., Columbus, Ohio, United States

  • UT Southwestern, Dallas, Texas, United States

  • The Childrenaaas Hospital of Philadelphia, Philadelphia, Pennsylvania, United States

  • Childrens Hospital Boston, Boston, Massachusetts, United States

  • Children's - East Ontario, Ottawa, Ontario, Canada

  • Cohens Childrens Medical Center of NY, New Hyde Park, New York, United States

  • University of North Carolina, Chapel Hill, North Carolina, United States

Locations

  • United States

  • Canada

Companies

  • N/A

Study Components

Therapeutic Area

  • Autoimmune (AI)

Disease

  • N/A

Biomarkers

  • Faecal calprotectin

  • Tumor necrosis factor

Drug/Treatment

  • Mesalamine

  • Infliximab

Outcome

  • Unknown

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Interim

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