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Mo1599 : PROTEASES IN COLONIC TISSUE FROM IBS PATIENTS EVOKE SUSTAINED EXCITABILITY OF NOCICEPTIVE DRG NEURONS VIA ENDOSOMAL SIGNALING

Researchers

Presenter

  • David E. Reed

Principal Investigators

  • Nigel W. Bunnett

  • Stephen Vanner

Medical Centers

  • School of Computing, Queens University, Kingston, ON, Canada

Locations

  • Canada

Companies

  • N/A

Study Components

Therapeutic Area

  • Gastroenterology (GU)

Disease

  • N/A

Biomarkers

  • Mitogen-activated protein kinase 3

  • Dual specificity mitogen-activated protein kinase kinase 1

  • Cathepsin S

  • Fragment 1+2

Drug/Treatment

  • Cysteine Hydrochloride

  • Trypsin

Outcome

  • Unknown

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Interim

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