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1972 : Inhibition of the Notch1 Pathway in Chronic Lymphocytic Leukemia Promotes Apoptosis and Inhibits Proliferation

Researchers

Presenter

  • Josephine L. Klitgaard

Principal Investigators

  • Reuma Magori-Cohen

  • Reina Improgo

  • Stacey M. Fernandes

  • Bethany Tesar

  • Kevin Hoang

  • Haesook T Kim

  • Jennifer R. Brown

Medical Centers

  • Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA

  • Departments of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston MA 02215, Boston, MA

  • Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA

  • Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, China

Locations

  • United States

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • T-cell acute lymphoblastic leukemia

  • Chronic Lymphocytic Leukemia

  • Acute lymphoblastic leukemia

Biomarkers

  • Annexin V

  • Neurogenic locus notch homolog protein 1

  • Cluster of Differentiation 19

  • Proliferation marker protein Ki-67

  • Granulin precursor

  • Immunoglobulin heavy-chain variable region gene

Drug/Treatment

  • PF-03084014

  • Ibrutinib

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Final

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