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OR03_50 : OXIDISED LDL ACTIVATES BLOOD PLATELETS THROUGH CD36-NADPH OXIDASE-MEDIATED INHIBITION OF THE CGMP/PROTEIN KINASE G SIGNALLING CASCADE.

Researchers

Presenter

  • S.G. Magwenzi

Principal Investigators

  • K.S. Wraith

  • N. Yuldasheva

  • S. Wheatcroft

  • M. Kearney

  • M. Febbriao

  • K. Naseem

Medical Centers

  • Division of Cardiovascular and Diabetes Research, University of Leeds, Leeds, United Kingdom

  • School of Dentistry, University of Alberta, Edmonton, United Kingdom

  • Centre for Cardiovascular and Metabolic Research, Hull York Medical School, Hull, United Kingdom

Locations

  • United Kingdom

Companies

  • N/A

Study Components

Therapeutic Area

  • Cardiovascular (CVS)

  • Blood/haematological Diseases

  • Pulmonary/Respiratory Diseases

Disease

  • Venous thrombosis

Biomarkers

  • Nicotinamide adenine dinucleotide phosphate oxidase

  • Oxidized LDL

  • Proto-oncogene tyrosine-protein kinase ROS

  • Spleen tyrosine kinase

Drug/Treatment

  • Nitric oxide

Outcome

  • Unknown

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Final

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