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4640 : Doxorubicin induced cardiomyopathy associated with natural reproductive hormone cycling in female tumor-bearing spontaneously hypertensive rats

Researchers

Presenter

  • Kaytee L. Pokrzywinski

Principal Investigators

  • Elliot T. Rosen

  • Julia Bonnano

  • Thomas Biel

  • Delaram Moshkelani

  • Baikuntha Aryal

  • Steven Mog

  • V. Ashutosh Rao

Medical Centers

  • Laboratory of Applied Biochemistry, Division of Biotechnology Review and Research III, Office of Biotechnology Research, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD.

  • Division of Process Assessment III, Office of Process and Facilities, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD

  • Office of Food Additive Safety, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, MD.

Locations

  • United States

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Heart muscle disease

  • Cardiotoxicity

  • Breast cancer

  • Solid malignancies

Biomarkers

  • Proto-oncogene tyrosine-protein kinase ROS

Drug/Treatment

  • ADR-529

  • Doxorubicin

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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