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11530 : CALIBRATE: Intensive profiling of circulating tumour DNA (ctDNA) from patients participating in experimental therapeutics trials including mutational profiles and copy number changes.

Researchers

Presenter

  • Javier Garcia-Corbacho

Principal Investigators

  • Hedley Carr

  • James Anthony Morris

  • Francesco Marrass

  • Davina Gillian Gale

  • Sanjeev Kumar

  • Mirela Hategan

  • Maricica Zabrautanu

  • William Dott

  • Elizabeth A. Harrington

  • Brian Andrew Dougherty

  • J Carl Barrett

  • Bristi Basu

  • James D. Brenton

  • Carlos Caldas

  • Duncan Ian Jodrell

  • Simon Pacey

  • Nitzan Rosenfeld

  • Richard D. Baird

Medical Centers

  • Early Phase Clinical Trials Team, Cambridge Cancer Centre, Cambridge, United Kingdom

  • Cancer Research UK Cambridge Institute, University of Cambridge., Cambridge, United Kingdom

  • AstraZeneca, Macclesfield, United Kingdom

  • Cancer Research UK Cambridge Institute, University of Cambridge., Cambridge, United Kingdom

  • Early Phase Clinical Trials Team, Cambridge Cancer Centre, Cambridge, United Kingdom

  • AstraZeneca, Waltham, MA

  • AstraZeneca, Boston, MA

  • Cambridge Cancer Centre, Cambridge, United Kingdom

  • Cancer Research UK Cambridge Institute, University of Cambridge., Cambridge, United Kingdom

Locations

  • United States

  • United Kingdom

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Solid malignancies

Biomarkers

  • Fibroblast growth factor receptor

  • Kinase Insert Domain Receptor

  • Serine/threonine-protein kinase mTOR

  • Circulating DNA

  • Plasma cell-free DNA

Drug/Treatment

  • N/A

Outcome

  • Unknown

Study Design

  • Pharmacokinetics

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Interim

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